Abstract: We measured the rate constants of the reaction between butanone and O（³P） with discharge flow-chemiluminescence method over the temperature rang 286—513K. The dependence of the rate constant on temperature determined is k=5.8±1.8×10^-11exp（-5.27±0.21kcal/RT）O（³P） atoms were produced by a discharge flow system and its residual concentration was detected by NO₂^* chemiluminescence which was produced by the reaction of O（³P） atoms with NO molecules added to the detector. The rate constants obtained for this reaction were compared with those reported for the reactions between O（³P） and alkanes.