Abstract: The kinetics and thermodynamics of hexadecylpyridiumchlorid in solvent sublation were studied.With the measurement of the surface forces at different temperatures and concentration，the freestandard adsorption energy ΔG0adswas obtained with - 33. 17kJ / mol. The process of solvent sublation ofhexadecylpyridiumchlorid is obedient to first order kinetics. The apparent rate coefficient decreases withthe increase of experiment temperature but increases with the increase of the air flow rates.