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Intracellular Self-assembly of TPE-biotin Nanoparticles Enables Aggregation-Induced Emission Fluorescence for Cancer-Targeted Imaging
Yi-fei Xu,Jin-hui Jiang*
Author NameAffiliationE-mail
Yi-fei Xu Department of Molecular and Cell Biology, University of Leicester, Leicester, LE1 7RH, UK  
Jin-hui Jiang* Department of Nuclear Medicine, The First A liated Hospital of Anhui Medical University, Hefei 230022, China jiangjinhui@ahmu.edu.cn 
Abstract:
Fluorogens with aggregation-induced emission (AIE) characteristics have recently been widely applied for studying biological events, and fluorogens with “smart” properties are especially desirable. Herein, we rationally designed and synthesized a biotinylated and reduction-activatable probe (Cys(StBu)-Lys(biotin)-Lys(TPE)-CBT (1)) with AIE properties for cancer-targeted imaging. The biotinylated probe 1 can be actively uptaken by the biotin receptor-overexpressing cancer cells, and then “smartly” self-assemble into nanoparticles inside cells and turn the fluorescence “On”. Employing this “smart” strategy, we successfully applied probe 1 for cancer-targeted imaging. We envision that this biotinylated intelligent probe 1 might be further developed for cancer-targeted imaging in routine clinical studies in the near future.
Key words:  Tetraphenylethylene, Biotin, Self-assembly, Aggregation-induced emission
FundProject:
胞内自组装四苯乙烯-生物素纳米粒子形成聚集诱导发光实现肿瘤细胞靶向显像
徐逸飞,蒋金辉*
摘要:
本文基于“聚集诱导发光”原理设计并合成了一种生物素化的可激活探针Cys(StBu)-Lys(biotin)-Lys(TPE)-CBT(1)用于肿瘤细胞靶向显像研究. 探针1能够被生物素受体高度表达的肿瘤细胞主动摄取,并在细胞内谷胱甘肽的还原作用下自组装形成纳米粒子结构导致“聚集诱导发光”. 基于这种“智能”的策略,本文成功地将探针1应用于肿瘤细胞的靶向显像研究. 这种生物素化的“智能”探针有望进一步发展应用于常规临床中的肿瘤显像.
关键词:  四苯乙烯,生物素,自组装,聚集诱导发光
DOI:10.1063/1674-0068/31/cjcp1806143
分类号: