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Ester-Derivatized Indoles as Fluorescent and Infrared Probes for Hydration Environments
Xin-yue Huang,Min You,Guang-liu Ran,Hao-ran Fan,Wen-kai Zhang*
Author NameAffiliationE-mail
Xin-yue Huang Department of Physics and Applied Optics Beijing Area Major Laboratory, Center for Advanced Quantum Studies, Beijing Normal University, Beijing 100875, China  
Min You Department of Physics and Applied Optics Beijing Area Major Laboratory, Center for Advanced Quantum Studies, Beijing Normal University, Beijing 100875, China  
Guang-liu Ran Department of Physics and Applied Optics Beijing Area Major Laboratory, Center for Advanced Quantum Studies, Beijing Normal University, Beijing 100875, China  
Hao-ran Fan Department of Chemistry, Beijing Normal University, Beijing 100875, China  
Wen-kai Zhang* Department of Physics and Applied Optics Beijing Area Major Laboratory, Center for Advanced Quantum Studies, Beijing Normal University, Beijing 100875, China wkzhang@bnu.edu.cn 
Abstract:
Tryptophan derivatives have long been used as site-specific biological probes. 4-Cyanotryptophan emits in the visible region and is the smallest blue fluorescent amino acid probe for biological applications. Other indole or tryptophan analogs may emit at even longer wavelengths than 4-cyanotryptophan. We performed FTIR, UV-Vis, and steady-state and time-resolved fluorescence spectroscopy on six ester-derivatized indoles in different solvents. Methyl indole-4-carboxylate emits at 450 nm with a long fluorescence lifetime, and is a promising candidate for a fluorescent probe. The ester-derivatized indoles could be used as spectroscopic probes to study local protein environments. Our measurements provide a guide for choosing esterderivatized indoles to use in practice and data for computational modeling of the effect of substitution on the electronic transitions of indole.
Key words:  Infrared probe  Fluorescent probe  Tryptophan derivative  Indole derivative
FundProject:This work was supported by Beijing Natural Science Foundation (L172028), the National Natural Science Foundation of China (No.21773012 and No.91753118), the Recruitment Program of Global Youth Experts and the Fundamental Research Funds for Central Universities.
酯基取代的吲哚衍生物的红外和荧光光谱研究
黄心悦,游敏,冉光柳,范浩然,张文凯*
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DOI:10.1063/1674-0068/31/cjcp1805118
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