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Controlled Synthesis of PCL/PVP Copolymer by RAFT Method and Its Hydrophilic Block-Dependent Micellar Behaviors
Rui Li,Wen-min Pang,Qing-ren Zhu,Kang-ming Nie
Author NameAffiliationE-mail
Rui Li Department of Biological and Environmental Engineering, Hefei University, Hefei 230022, China  
Wen-min Pang Hefei National Laboratory for Physical Science at the Microscale, University of Science and Technology of China, Hefei 230026, China  
Qing-ren Zhu Hefei National Laboratory for Physical Science at the Microscale, University of Science and Technology of China, Hefei 230026, China  
Kang-ming Nie Anhui Province Key Laboratory of Environment-Friendly Polymer Materials, College of Chemistry and Chemical Engineering, Anhui University, Hefei 230601, China niekm@ahu.edu.cn 
Abstract:
A range of poly(ε-caprolactone)/poly(N-vinyl-2-pyrrolidone) amphiphilic block copolymers with well-de ned hydrophilic chain length were synthesized by the living/controlled reversible addition fragmentation chain transfer polymerization method. The composition and struc-ture of the targeted resultants were characterized with 1H NMR, 13C NMR, FT-IR spec-troscopy and gel permeation chromatography. The various block copolymers were success-fully employed to fabricate the spherical micelle with core-shell morphological structure. The poly(N-vinyl-2-pyrrolidone) block-dependent characteristics of the copolymeric micelles were investigated by uorescence spectroscopy, dynamic light scattering, and transmission electron microscopy. The solubilization of the hydrophobic ibuprofen as a model drug in the micelle solution was also explored. It was found that the drug loading contents are related to the micellar morphology structure determined by hydrophilic chain length in the copolymer.
Key words:  RAFT polymerization  Poly(N-vinyl-2-pyrrolidone)  Core-shell structure  Hydrophilic chain length  Micellar behavior
FundProject:This work was supported by the National Natural Science Foundation of China (No.50973001), the Key Science and Research Project of Anhui Province Edu-cation Department, China (No.KJ2012A018), and the Talent Science Research Foundation of Hefei University, China (No.14RC04).
RAFT控制合成PCL/PVP共聚物及其胶束行为的亲水链依赖性
李蕤,庞文民,朱清仁,聂康明
摘要:
可逆-加成-断裂-链转移聚合方法合成了系列具有确定亲水性链长的聚(己内酯)/聚(N-乙烯-2-吡咯烷酮)两亲性嵌段共聚物.使用核磁共振氢谱、碳谱、红外光谱和凝胶渗透色谱表征了目标产物的组成和结构.不同亲水链长的嵌段共聚物被成功用于具有核-壳形貌结构的球形胶束的组装.应用荧光光谱,动态光散射和透射电子显微镜研究了依赖于聚(N-乙烯-2-吡咯烷酮)亲水性链长的共聚物胶束特性.以疏水性布洛芬作为药物模型,探索了该共聚物胶束作为纳米药物载体的负载行为.发现其药物负载量与共聚物中亲水链长度确定的球形胶束载体的形貌结构相关联.
关键词:  可逆-加成-断裂-链转移聚合  聚(N-乙烯-2-吡咯烷酮)  核-壳结构  亲水性链长  胶束行为
DOI:10.1063/1674-0068/29/cjcp1509203
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