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Intracellular self-assembly of TPE-biotin nanoparticles enables aggregation-induced emission fluorescence for cancer-targeted imaging
JiangJinhui
Author NameAffiliationE-mail
JiangJinhui Department of Nuclear Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China jjhui@mail.ustc.edu.cn 
Abstract:
Fluorogens with aggregation-induced emission(AIE) characteristics have recently been widely applied for studying biological events, and those with “smart” properties are especially desirable. Herein, we rationally designed and synthesized a biotinylated and reduction-activatable probe Cys(StBu)-Lys(biotin)-Lys(TPE)-CBT (1) with aggregation-induced emission (AIE) properties for cancer-targeted imaging. The biotinylated probe 1 could be actively uptaken by the biotin receptor-overexpressing cancer cells, and “smartly” self-assembled into nanoparticles inside cells turned the fluorescence “On”. Employing this “smart” strategy, we successfully applied probe 1 for cancer-targeted imaging. We envision that this biotinylated intelligent probe 1 might be further developed for cancer-targeted imaging in routine clinical studies in the near future.
Key words:  Tetraphenylethylene, Biotin, Self-assembly, Aggregation-induced emission
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Intracellular self-assembly of TPE-biotin nanoparticles enables aggregation-induced emission fluorescence for cancer-targeted imaging
JiangJinhui
摘要:
Fluorogens with aggregation-induced emission(AIE) characteristics have recently been widely applied for studying biological events, and those with “smart” properties are especially desirable. Herein, we rationally designed and synthesized a biotinylated and reduction-activatable probe Cys(StBu)-Lys(biotin)-Lys(TPE)-CBT (1) with aggregation-induced emission (AIE) properties for cancer-targeted imaging. The biotinylated probe 1 could be actively uptaken by the biotin receptor-overexpressing cancer cells, and “smartly” self-assembled into nanoparticles inside cells turned the fluorescence “On”. Employing this “smart” strategy, we successfully applied probe 1 for cancer-targeted imaging. We envision that this biotinylated intelligent probe 1 might be further developed for cancer-targeted imaging in routine clinical studies in the near future.
关键词:  Tetraphenylethylene, Biotin, Self-assembly, Aggregation-induced emission
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