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Gd doped hollow nanoscale coordination polymers as multimodal imaging agents and a potential drug delivery carriers
GuoZhen
Author NameAffiliationE-mail
GuoZhen Anhui Key Laboratory for Cellular Dynamics and Chemical Biology, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China zgz@mail.ustc.edu.cn 
Abstract:
Gd doped hollow nanoscale coordination polymers with multimodal imaging capabilities were synthesized by solvothermal method and further coated by silica layer. The in-vitro tests demonstrated uncoated and silica-coated nanoprobes exhibit longitudinal relaxivities (r1) of 7.38 mM-1 s-1, 13.57 mM-1 s-1 and transverse relaxivities (r2) of 180.6 mM-1 s-1, 304.8 mM-1 s-1, showing fairly good dual T1 &T2 contrast effects, and it also emits excellent multicolor ?uorescence under laser beams of various wavelengths. With the combination of MRI (both T1 and T2) and fluorescence optical imaging (FOI), the nanoprobes could correlate preoperative diagnosis with intraoperative pathology. Furthermore, it also exhibits high drug loading capacity of 1166mg/g and encapsulation ef?ciency of 83.29%, which makes it a potential platform as drug carriers. The MTT assay demonstrates the moderate toxicity of the NPs, and after the silica coating process, not only the MRI contrast effects but also the biocompatibility have been enhanced. The versatility of the highly integrated systems can make up for the limitations of each imaging modality and exhibit great potentials for cancer theranostics.
Key words:  Coordination polymers MRI Fluorescence optical imaging Drug delivery potentials
FundProject:
钆掺杂的类普鲁士蓝空心配位聚合物作为多模式成像探针及药物载体的研究
GuoZhen
摘要:
我们通过溶剂热法制备了具有多模式成像能力的钆掺杂的类普鲁士蓝空心配位聚合物,并包覆二氧化硅层以进一步应用。磁共振成像实验表明纳米粒子表现出相当好的双模式(T1和T2)磁共振成像能力,其纵向弛豫率(r1)在二氧化硅层包覆前后分别为7.38 mM-1 s-1, 13.57 mM-1 s-1,而横向弛豫率(r2)在包覆前后分别为180.6 mM-1 s-1,304.8 mM-1 s-1。此外,在各种波长的激光束下纳米粒子也会发出多色荧光。这种结合了磁共振成像MRI(T1和T2)和荧光光学成像(FOI)能力的纳米探针可将术前诊断与术中病理学联系起来。此外,得益于空心多孔结构它还具有1166mg/g的高载药(阿霉素)能力和83.29%的药物封装效率,这使其成为潜在的药物载体平台。 细胞毒性实验证实粒子毒性并不大,特别在二氧化硅包覆之后,不仅磁共振对比效果,而且生物相容性也都得到了增强。这种高度集成具备多功能的平台可以有效弥补单个成像模式的局限性,并具备诊疗一体化的潜力。
关键词:  配位聚合物, 磁共振成像, 荧光成像, 药物载体
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