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Optimal Internal Noise for Mammalian Circadian Oscillator
Zhi-wei Wang ,Zhong-huai Hou*,Hou-wen Xin*
Author NameAffiliation
Zhi-wei Wang Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, China; Teda Bio-X Research Center, Tianjin University of Science and Technology, Tianjin 300457,China 
Zhong-huai Hou* Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, China; 
Hou-wen Xin* Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, China; 
Abstract:
Based on a deterministic mammalian circadian oscillator proposed recently, we have constructed the corresponding mesoscopic stochastic model, and studied the effect of internal noise on the genetic oscillations of such a system. It is found that the stochastic genetic oscillations can show best performance at an optimal internal noise level via a mechanism of internal noise stochastic resonance. Furthermore, it is found that there exists a moderate system size that makes the stochastic model show effective oscillation at more extended region than the deterministic description, which indicates enhanced robustness as the result of internal noise. The potential biological application of such an effect is also discussed.
Key words:  Internal noise, Genetic oscillation, Mesoscopic size e?ect, Stochastic resonance, Chemical langevin equation
FundProject:This work was supported by the National Natural Science Foundation of China (No.20673106 and No.20433050), the Author of National Excellent Doctoral Dissertation of PR China (FANEDD).
哺乳动物生理振荡中的最佳内噪声效应
王志伟,侯中怀* ,辛厚文*
摘要:
基于哺乳动物生理振子模型,构造了相应的介观随机模型,研究了该系统中内噪声对基因振荡的影响.结果发现通过内噪声随机共振的机制,随机的基因振荡可以在最佳内噪声水平处达到最佳状态.同时,还发现存在一个中间的系统尺度使得随机模型表现出比确定性模型更宽的有效振荡区域,这说明了内噪声增强了体系的鲁帮性.讨论了这些效应可能的生理意义.
关键词:  内噪声,基因振荡,介观尺度效应,随机共振,化学朗之万方程
DOI:10.1360/cjcp2007.20(2).119.7
分类号: