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Pyrene Solubilization in Aqueous Micellar Solutions of Pluronic Block Copolymers
Zhao Jianxi,Jiang Linqin,Chen Ying,Dai Minguanga
Author NameAffiliation
Zhao Jianxi Department of Chemistry,Fuzhou University,FuZhou 350002 
Jiang Linqin Department of Chemistry,Fuzhou University,FuZhou 350002 
Chen Ying Central Laboratory,Fuzhou University,FuZhou 350002 
Dai Minguanga Department of Chemistry,Fuzhou University,FuZhou 350002 
Abstract:
Micelles of Pluronic block copolymers have recently displayed a potential application as drug microcarriers.In the application,one of the key problems is effective solubilization of hydrophobic drugs in the micelles.However,solubilization regularities of hydrophobic materials in Pluronic micelles have not been fully studied.In this paper,the solubilization of pyrene(Py)in the aqueous micellar solutions of Pluronic block copolymers has been investigated by steady-state fluorescent spectra.The results showed that the PPO content in Pluronic molecule is a key factor to determine Py amount adsorbed in the micelles.The greater is the PPO content,the much favorably solubilizate Py in the micelles.In the molecules of Pluronic copolymers studied in this paper,PPO content orders as F108(2920)>P85(2300)>F68(1680)and thus the partition coefficients(KV)of Py between the micelles and water are 8.3×104(F108,35℃),5.7×104(P85,35℃)and 2.2×103(F68,40℃),respectively.Addition of KCl leads to formation of the larger micelle with less hydrated shell.This means formation of a larger micellar core available to accommodating hydrophobic Py molecules,which is in agreement with the experimental results that showed an enhancement in Py solubilization as addition of KCl.
Key words:  Pluronic block copolymer,Partition coefficient,Micelle solubilization
FundProject:福建省自然科学基金、福建省高校科技项目和国家教委留学回国人员科研启动基金资助
芘在Pluronic两亲嵌段共聚物胶团中的增溶
赵剑曦,江琳沁,陈颖,戴闽光
摘要:
用稳态荧光法研究芘(Py)在Pluronic两亲嵌段共聚物胶团水溶液中的增溶,结果表明共聚物分子中的PPO实际含量越大,越有利于Py的增溶。加入无机盐KCl导致生成了表面较少水化的较大胶团,并且由于KCl解离产生的离子使溶剂极性增加,这些因素促进了Py的增溶。
关键词:  Pluronic嵌段共聚物  分配系数  胶团增溶
DOI:10.1088/1674-0068/13/1/123-128
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