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Alginate-Coated Fe3O4 Hollow Microspheres for Drug Delivery
Li-juan Donga*,Gu Jinb
Author NameAffiliationE-mail
Li-juan Donga* College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China donglj@mail.zjgsu.edu.cn 
Gu Jinb Department of Chemistry, University of Science and Technology of China, Hefei 230026, China  
Abstract:
Novel hollow Fe3O4 nanoparticles for drug delivery were synthesized via a one-step templatefree approach. These nanoparticles were obtained by modifing the Fe3O4 nanoparticles with 3-aminopropyltrimethoxy silane, and then grafting alginate onto the surface of amine magnetic. The hollow structure of Fe3O4 spheres was characterized by TEM, XRD, and XPS. The M-H hysteresis loop indicated that the magnetic spheres exhibit superparamagnetic characteristics at room temperature. Daunorubicin acting as a model drug was loaded into the carrier, and the maximum percent of envelop and load were 28.4% and 14.2% respectively. The drug controlled releasing behaviors of the carriers were compared in different pH media.
Key words:  Hollow Fe3O4 nanoparticles  3-Aminopropyltrimethoxy silane  Drug delivery
FundProject:
海藻酸改性的空心Fe3O4纳米颗粒的制备与应用
董丽娟a*,金谷b
摘要:
不使用任何模板一步制得空心Fe3O4纳米颗粒,然后将海藻酸钠嫁接在氨基化的空心Fe3O4表面,再利用海藻酸盐与钙离子的作用,在空心Fe3O4表面形成一个凝胶化层,制得海藻酸盐凝胶化的空心Fe3O4纳米颗粒,粒径约为400~500 nm.采用TEM、XRD、XPS、VSM等手段对纳米微球进行表征.VSM表征结果表明在室温下样品磁性材料为超顺磁性.改性Fe3O4纳米颗粒成功地用于柔红霉素的载负和缓释,最大载负率和载药量分别为28.4%和14.2%.缓释结果表明,海藻酸盐凝胶化层的存在,能更有效控制柔红霉素缓慢地释放.
关键词:  空心Fe3O4纳米颗粒  APTMs  海藻酸盐  药物载体
DOI:10.1063/1674-0068/28/cjcp1411191
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