海藻酸改性的空心Fe<sub>3</sub>O<sub>4</sub>纳米颗粒的制备与应用

董丽娟<sup>a*</sup>; 金谷<sup>b</sup>

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Alginate-Coated Fe₃O₄ Hollow Microspheres for Drug Delivery
Li-juan Dong^a*,Gu Jin^b

Author Name	Affiliation	E-mail
Li-juan Dong^a*	College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China	donglj@mail.zjgsu.edu.cn
Gu Jin^b	Department of Chemistry, University of Science and Technology of China, Hefei 230026, China

Abstract:

Novel hollow Fe₃O₄ nanoparticles for drug delivery were synthesized via a one-step templatefree approach. These nanoparticles were obtained by modifing the Fe₃O₄ nanoparticles with 3-aminopropyltrimethoxy silane, and then grafting alginate onto the surface of amine magnetic. The hollow structure of Fe₃O₄ spheres was characterized by TEM, XRD, and XPS. The M-H hysteresis loop indicated that the magnetic spheres exhibit superparamagnetic characteristics at room temperature. Daunorubicin acting as a model drug was loaded into the carrier, and the maximum percent of envelop and load were 28.4% and 14.2% respectively. The drug controlled releasing behaviors of the carriers were compared in different pH media.

Key words: Hollow Fe₃O₄ nanoparticles 3-Aminopropyltrimethoxy silane Drug delivery

FundProject:

海藻酸改性的空心Fe₃O₄纳米颗粒的制备与应用

董丽娟^a*,金谷^b

摘要:

不使用任何模板一步制得空心Fe₃O₄纳米颗粒，然后将海藻酸钠嫁接在氨基化的空心Fe₃O₄表面，再利用海藻酸盐与钙离子的作用，在空心Fe₃O₄表面形成一个凝胶化层，制得海藻酸盐凝胶化的空心Fe₃O₄纳米颗粒，粒径约为400～500 nm．采用TEM、XRD、XPS、VSM等手段对纳米微球进行表征．VSM表征结果表明在室温下样品磁性材料为超顺磁性．改性Fe₃O₄纳米颗粒成功地用于柔红霉素的载负和缓释，最大载负率和载药量分别为28.4%和14.2%．缓释结果表明，海藻酸盐凝胶化层的存在，能更有效控制柔红霉素缓慢地释放．

关键词: 空心Fe3O4纳米颗粒 APTMs 海藻酸盐药物载体

DOI：10.1063/1674-0068/28/cjcp1411191

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