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| Alginate-Coated Fe3O4 Hollow Microspheres for Drug Delivery |
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Li-juan Dong1, Gu Jin2
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1.College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China;2.Department of Chemistry, University of Science and Technology of China, Hefei 230026, China
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| Abstract: |
| Novel hollow Fe3O4 nanoparticles for drug delivery were synthesized via a one-step templatefree approach. These nanoparticles were obtained by modifing the Fe3O4 nanoparticles with 3-aminopropyltrimethoxy silane, and then grafting alginate onto the surface of amine magnetic. The hollow structure of Fe3O4 spheres was characterized by TEM, XRD, and XPS. The M-H hysteresis loop indicated that the magnetic spheres exhibit superparamagnetic characteristics at room temperature. Daunorubicin acting as a model drug was loaded into the carrier, and the maximum percent of envelop and load were 28.4% and 14.2% respectively. The drug controlled releasing behaviors of the carriers were compared in different pH media. |
| Key words: Hollow Fe3O4 nanoparticles 3-Aminopropyltrimethoxy silane Drug delivery |
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附件 |
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| 海藻酸改性的空心Fe3O4纳米颗粒的制备与应用 |
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董丽娟1, 金谷2
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1.浙江工商大学食品科学与生物技术学院，杭州 310018;2.中国科学技术大学化学系，合肥 230026
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| 摘要: |
| 不使用任何模板一步制得空心Fe3O4纳米颗粒，然后将海藻酸钠嫁接在氨基化的空心Fe3O4表面，再利用海藻酸盐与钙离子的作用，在空心Fe3O4表面形成一个凝胶化层，制得海藻酸盐凝胶化的空心Fe3O4纳米颗粒，粒径约为400～500 nm．采用TEM、XRD、XPS、VSM等手段对纳米微球进行表征．VSM表征结果表明在室温下样品磁性材料为超顺磁性．改性Fe3O4纳米颗粒成功地用于柔红霉素的载负和缓释，最大载负率和载药量分别为28.4%和14.2%．缓释结果表明，海藻酸盐凝胶化层的存在，能更有效控制柔红霉素缓慢地释放． |
| 关键词: 空心Fe3O4纳米颗粒 APTMs 海藻酸盐 药物载体 |
| DOI：10.1063/1674-0068/28/cjcp1411191 |
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