引用本文:
【打印本页】   【HTML】   【下载PDF全文】   View/Add Comment  【EndNote】   【RefMan】   【BibTex】
←前一篇|后一篇→ 过刊浏览    高级检索
本文已被:浏览 1519次   下载 1139 本文二维码信息
码上扫一扫!
分享到: 微信 更多
Synthesis of an Amphiphilic Dendrimer-Like Block Copolymer and Its Application on Drug Delivery
Shuai-peng Wang,Xiao-wan Song,Xiao-shuang Feng*,Peng Chen*,Jia-sheng Qian,Ru Xia,Ji-bin Miao
Author NameAffiliationE-mail
Shuai-peng Wang School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Hefei 230601, China  
Xiao-wan Song School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Hefei 230601, China  
Xiao-shuang Feng* Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia fxs101@gmail.com 
Peng Chen* School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Hefei 230601, China chpecp@126.com 
Jia-sheng Qian School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Hefei 230601, China  
Ru Xia School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Hefei 230601, China  
Ji-bin Miao School of Chemistry and Chemical Engineering, Anhui University, Key Laboratory of Environment-friendly Polymer Materials of Anhui Province, Hefei 230601, China  
Abstract:
Dendrimer-like amphiphilic copolymer is a kind of three-dimensional spherical structure polymer. An amphiphilic dendrimer-like diblock copolymer, PEEGE-G2-b-PEO(OH)12, constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were charac-terized with 1H NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH)12 using DOX as a model drug was also studied. The drug loading content and encapsulation e ciency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media.
Key words:  Anionic ring opening polymerization, Living polymerization, Dendrimer-like copolymer, Amphiphilic diblock copolymer, Drug delivery
FundProject:
两亲性类树枝状聚合物的合成与药物控释
王帅鹏,宋晓婉,冯晓双*,陈鹏*,钱家盛,夏茹,苗继斌
摘要:
结合阴离子开环聚合方法合成了内壳为聚(乙氧基乙基缩水甘油醚),外层为聚环氧乙烷的两亲性类树枝状嵌段共聚物PEEGE-G2-b-PEO(OH)12. 使用核磁共振氢谱以及凝胶渗透色谱等表征了中间产物和目标产物. 选择阿霉素作为实验药物,研究了该聚合物的载药和控释行为. 聚合物的载药率和包覆效率分别为13.07%和45.75%,体外释放试验表现为持续性的释放,并受到释放介质pH影响.
关键词:  阴离子开环聚合,活性聚合,类树枝状聚合物,两亲性嵌段聚合物,药物缓释
DOI:10.1063/1674-0068/27/05/587-592
分类号: