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Fabrication of Monodisperse “Core-Satellite” Nanostructures by DNA-Programming: a Novel Class of Superstructured Building Blocks for Hierarchical Nanoassembly
Yang Yang,Xue Bai,Ling-ling Fang,Zhao-xiang Deng*
Author NameAffiliationE-mail
Yang Yang CAS Key Laboratory of Soft Matter Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, University of Science and Technology of China, Hefei 230026, China  
Xue Bai CAS Key Laboratory of Soft Matter Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, University of Science and Technology of China, Hefei 230026, China  
Ling-ling Fang CAS Key Laboratory of Soft Matter Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, University of Science and Technology of China, Hefei 230026, China  
Zhao-xiang Deng* CAS Key Laboratory of Soft Matter Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, University of Science and Technology of China, Hefei 230026, China zhxdeng@ustc.edu.cn 
Abstract:
Monodisperse nanoparticle assembly with tunable structure, composition and properties can be taken as a superstructured building block for the construction of hierarchical nanostruc-tures from the bottom up, which also represents a great challenge in nanotechnology. Here we report on a facile and controllable method that enables a high yield fabrication of uniform gold nanoparticle (AuNP) core-satellites with definable number (in average) of the satellite particles and tunable core-to-satellite distance. The formation of the core-satellite nanostruc-tures is driven by programmable DNA-basepairing, with the resulting nanocomplexes being isolatable via gel electrophoresis. By rationally controlling the DNA coverages on the core and shell particles, high production yields are achieved for the assembly/isolation process. As well, benefiting from a minimum DNA coverage on the satellite AuNPs, a strong affinity is observed for the as-prepared core-satellites to get adsorbed on protein-coated graphene ox-ide, which allows for a two-dimensional hierarchical assembly of the core-satellite structures. The resulting hierarchical nanoassemblies are expected to find applications in various areas, including plasmonics, biosensing, and nanocatalysis. The method should be generalizable to make even more complicated and higher-order structures by making use of the structural programmability of DNA molecules.
Key words:  Core-satellite, DNA nanoassembly, Graphene oxide, Gold nanoparticle, Hier-archical structure
FundProject:
单分散“核-卫星”金纳米结构的DNA控制组装:一种新型的纳米分级组装模块
杨扬,白雪,方玲玲,邓兆祥*
摘要:
报道了一种单分散“核-卫星”纳米金簇状结构的构造方法,不但可以有效调节卫星粒子的数目,还能实现核与卫星粒子间距离的准确控制. 利用DNA分子高度可控的程序化自组装性能,通过合理控制组装过程中核与卫星粒子表面的DNA修饰密度以及不同金纳米粒子的化学计量比,实现了单分散核-卫星结构的高产率组装,结合使用凝胶电泳这一高效的纳米分离技术实现了目标产物的分离. 该方法保证了卫星粒子表面极低的DNA覆盖率,使其与蛋白分子中的巯基基团具有较强的化学亲和作用,使得金纳米粒子在蛋白功能化石墨烯表面的二维层次化自组装得以实现.
关键词:  核-卫星结构,DNA纳米组装,氧化石墨烯,纳米金,分级纳米结构
DOI:10.1063/1674-0068/26/05/601-606
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