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Interaction of Egg-Sphingomyelin with DOPC in Langmuir Monolayers
Chang-chun Hao*1, Run-guang Sun1, Jing Zhang2
1.College of Physics and Information Technology, Shaanxi Normal University, Xi'an 710062, China;2.College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710062, China
Abstract:
Lipid rafts are a dynamic microdomain structure found in recent years, enriched in sphin-golipids, cholesterol and particular proteins. The change of structure and function of lipid rafts could result in many diseases. In this work, the monolayer miscibility behavior of mixed systems of Egg-Sphingomyelin (ESM) with 1, 2-dioleoyl-sn-glycero-3-phosphocholine was in-vestigated in terms of mean surface area per molecule and excess molecular area ΔAex at certain surface pressure, surface pressure and excess surface pressure Δπex at certain mean molecular area. The stability and compressibility of the mixed monolayers was assessed by the parameters of surface excess Gibbs free energy ΔGex, excess Helmholtz energy ΔHex and elasticity. Thermodynamic analysis indicates ΔAex and Δπeex in the binary systems with positive deviations from the ideal behavior, suggesting repulsive interaction. The max-imum of ΔGex and ΔHex was at the molar fraction of ESM of 0.6, demonstrating the mixed monolayer was more unstable. The repulsive interaction induced phase separation in the monolayer
Key words:  Monolayer, Attractive and repulsive interaction, Stability, Phase separation
FundProject:
卵黄鞘磷脂与DOPC相互作用的单层膜
郝长春*1, 孙润广1, 张静2
1.陕西师范大学物理学与信息技术学院,西安710062;2.陕西师范大学食品工程与营养科学学院,西安 710062
摘要:
通过分析单层膜在固定表面压力下的过量分子面积和固定分子面积时的过量表面压力研究了卵黄鞘磷脂和1,2-二油酸基磷脂酰胆碱在单层膜中的混合性行为,通过分析过量吉布斯能量、过量亥姆霍兹能量和弹性系数评估了混合脂单层膜稳定性和压缩性. 热力学分析表明,相对于两组分理想混合时过量分子面积和过量表面压力呈现出正偏差,表明分子间的相互作用力为排斥力. 能量极值点出现在卵黄鞘磷脂含量为0.6处,表明该比例下单层膜结构状态不稳定. 排斥力诱导了单层膜中产生相分离.
关键词:  单层膜,吸引排斥相互作用,稳定性,相分离
DOI:10.1088/1674-0068/25/06/691-696
分类号: