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具有双重治疗机制的磁性纳米无定型氧化铁基药物递送系统
雷 珊1, 王黎安1, 林福星*2, 曾 琨1, 汪谟贞*1, 葛学武1
1.中国科学院软物质化学重点实验室,中国科学技术大学高分子科学与工程系,合肥 230026;2.三明学院资源与化工学院,三明市氟化工产业技术研究院,三明 365004
摘要:
合成一种具有pH响应性的聚乙二醇(PEG)修饰无定形介孔氧化铁纳米粒子(AFe-PEG). 这种纳米粒子可以高效负载药物分子如阿霉素(DOX),构成新型多功能AFe-PEG/DOX药物递送体系. DOX的负载率高达948 mg/g-纳米粒子. 在酸性溶液中,AFe-PEG/DOX纳米粒子不仅可以有效释放DOX,同时可以释放Fe离子进行Fenton反应,将H2O2转变成·OH自由基. 体外实验结果表明,AFe-PEG/DOX纳米粒子对HeLa细胞同时具有化疗和化学动力学疗法的疗效. 同时,由于AFe-PEG/DOX 纳米粒子本身的磁性,使其在外部磁场中的细胞内化效率也得到了提高.
关键词:  立方无定形氧化铁,pH响应性,化学疗法,化学动力学治疗,磁靶向递送
DOI:10.1063/1674-0068/cjcp1906123
分类号:
基金项目:
Magnetic Nano-Amorphous-Iron-Oxide-Based Drug Delivery System with Dual Therapeutic Mechanisms
Shan Lei1, Li-an Wang1, Fu-xing Lin*2, Kun Zeng1, Mo-zhen Wang*1, Xue-wu Ge1
1.CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China;2.College of Resources and Chemical Engineering, Fujian Engineering Research Center for Advanced Fluorine-containing Materials, Sanming University, Sanming 365004, China
Abstract:
Smart nanoparticles that respond to pathophysiological parameters, such as pH, GSH, and H2O2, have been developed with the huge and urgent demand for the high-efficient drug delivery systems (DDS) for cancer therapy. Herein, cubic poly(ethylene glycol) (PEG)-modified mesoporous amorphous iron oxide (AFe) nanoparticles (AFe-PEG) have been successfully prepared as pH-stimulated drug carriers, which can combine doxorubicin (DOX) with a high loading capacity of 948 mg/g, forming a novel multifunctional AFe-PEG/DOX nanopartic-ulate DDS. In an acidic microenvironment, the AFe-PEG/DOX nanoparticles will not only release DOX efficiently, but also release Fe ions to catalyze the transformation of H2O2 to·OH, acting as fenton reagents. In vitro experimental results proved that the AFe-PEG/DOX nanoparticles can achieve combination of chemotherapeutic (CTT) and chemodynamic therapeutic (CDT) effects on Hela tumor cells. Furthermore, the intrinsic magnetism of AFe-PEG/DOX makes its cellular internalization efficiency be improved under an external mag-netic field. Therefore, this work develops a new and promising magnetically targeted delivery and dual CTT/CDT therapeutic nano-medicine platform based on amorphous iron oxide.
Key words:  Cubic amorphous iron oxide nanoparticles, pH-responsive, Chemotherapy, Chemodynamic therapy, Magnetically targeted delivery
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