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钆掺杂的类普鲁士蓝空心配位聚合物作为多模式成像探针及药物载体的研究
赵高正,郭 振*,陈乾旺*
作者单位E-mail
赵高正 中国科学技术大学材料科学与工程系合肥微尺度物质科学国家研究中心合肥 230026  
郭 振* 中国科学技术大学生命科学学院安徽省细胞动力学和化学生物学实验室合肥 230026 zhenguo@ustc.edu.cn 
陈乾旺* 中国科学技术大学材料科学与工程系合肥微尺度物质科学国家研究中心合肥 230026 cqw@ustc.edu.cn 
摘要:
本文通过溶剂热法制备了具有多模式成像能力的钆掺杂的类普鲁士蓝空心配位聚合物,并包覆二氧化硅层以进一步应用. 磁共振成像实验表明纳米粒子表现出相当好的双模式磁共振成像能力. 此外,在各种波长的激光束下纳米粒子也会发出多色荧光. 由于其空心多孔结构,该聚合物具有1166 mg/g的高载药(阿霉素)能力和83.29%的药物封装效率,这使其成为潜在的药物载体平台. 特别在二氧化硅包覆之后,生物相容性也都得到了增强.
关键词:  配位聚合物,磁共振成像,荧光成像,药物载体
DOI:10.1063/1674-0068/31/cjcp1805100
分类号:
基金项目:
Gd Doped Hollow Nanoscale Coordination Polymers as Multimodal Imaging Agents and a Potential Drug Delivery Carriers
Gao-zheng Zhao,Zhen Guo*,Qian-wang Chen*
Abstract:
Gd doped hollow nanoscale coordination polymers with multimodal imaging capabilities were synthesized by solvothermal method and further coated by silica layer. The in vitro tests demonstrated uncoated and silica-coated nanoprobes exhibit longitudinal relaxivities (r1) of 7.38 and 13.57 (mmol/L)-1·s-1, and transverse relaxivities (r2) of 180.6 and 304.8 (mmol/L)-1·s-1, showing fairly good dual T1&T2 contrast effects, and it also emits excellent multicolor fluorescence under laser beams of various wavelengths. With the combination of magnetic resonance imaging (MRI) (both T1 and T2) and fluorescence optical imaging (FOI), the nanoprobes could correlate preoperative diagnosis with intraoperative pathology. Furthermore, it also exhibits high drug loading capacity of 1166 mg/g and encapsulation efficiency of 83.29%, which makes it a potential platform as drug carriers. The MTT assay demonstrates the moderate toxicity of the NPs, and after the silica coating process, not only the MRI contrast effects but also the biocompatibility have been enhanced. The versatility of the highly integrated systems can make up for the limitations of each imaging modality and exhibit great potentials for cancer theranostics.
Key words:  Coordination polymers, Magnetic resonance imaging, Fluorescence optical imaging, Drug delivery potentials