Zhi-wei Wang, Zhong-huai Hou, Hou-wen Xin. Optimal Internal Noise for Mammalian Circadian Oscillator[J]. Chinese Journal of Chemical Physics , 2007, 20(2): 119-125. doi: 10.1360/cjcp2007.20(2).119.7
Citation: Zhi-wei Wang, Zhong-huai Hou, Hou-wen Xin. Optimal Internal Noise for Mammalian Circadian Oscillator[J]. Chinese Journal of Chemical Physics , 2007, 20(2): 119-125. doi: 10.1360/cjcp2007.20(2).119.7

Optimal Internal Noise for Mammalian Circadian Oscillator

doi: 10.1360/cjcp2007.20(2).119.7
Funds:  This work was supported by the National Natural Science Foundation of China (No.20673106 and No.20433050), the Author of National Excellent Doctoral Dissertation of PR China (FANEDD).
  • Received Date: 2006-06-07
  • Based on a deterministic mammalian circadian oscillator proposed recently, we have constructed the corresponding mesoscopic stochastic model, and studied the effect of internal noise on the genetic oscillations of such a system. It is found that the stochastic genetic oscillations can show best performance at an optimal internal noise level via a mechanism of internal noise stochastic resonance. Furthermore, it is found that there exists a moderate system size that makes the stochastic model show effective oscillation at more extended region than the deterministic description, which indicates enhanced robustness as the result of internal noise. The potential biological application of such an effect is also discussed.
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Optimal Internal Noise for Mammalian Circadian Oscillator

doi: 10.1360/cjcp2007.20(2).119.7
Funds:  This work was supported by the National Natural Science Foundation of China (No.20673106 and No.20433050), the Author of National Excellent Doctoral Dissertation of PR China (FANEDD).

Abstract: Based on a deterministic mammalian circadian oscillator proposed recently, we have constructed the corresponding mesoscopic stochastic model, and studied the effect of internal noise on the genetic oscillations of such a system. It is found that the stochastic genetic oscillations can show best performance at an optimal internal noise level via a mechanism of internal noise stochastic resonance. Furthermore, it is found that there exists a moderate system size that makes the stochastic model show effective oscillation at more extended region than the deterministic description, which indicates enhanced robustness as the result of internal noise. The potential biological application of such an effect is also discussed.

Zhi-wei Wang, Zhong-huai Hou, Hou-wen Xin. Optimal Internal Noise for Mammalian Circadian Oscillator[J]. Chinese Journal of Chemical Physics , 2007, 20(2): 119-125. doi: 10.1360/cjcp2007.20(2).119.7
Citation: Zhi-wei Wang, Zhong-huai Hou, Hou-wen Xin. Optimal Internal Noise for Mammalian Circadian Oscillator[J]. Chinese Journal of Chemical Physics , 2007, 20(2): 119-125. doi: 10.1360/cjcp2007.20(2).119.7

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