Cai Hong, Zhang Zhanjun, Wang Bin, Li Yuhui, Cai Shengmin. Studies of Electrochemical Sensoral Behavior of Histamine Based on the Solid Supported Bilayer Lipid Membrane[J]. Chinese Journal of Chemical Physics , 2004, 17(2): 206-210. doi: 10.1088/1674-0068/17/2/206-210
Citation: Cai Hong, Zhang Zhanjun, Wang Bin, Li Yuhui, Cai Shengmin. Studies of Electrochemical Sensoral Behavior of Histamine Based on the Solid Supported Bilayer Lipid Membrane[J]. Chinese Journal of Chemical Physics , 2004, 17(2): 206-210. doi: 10.1088/1674-0068/17/2/206-210

Studies of Electrochemical Sensoral Behavior of Histamine Based on the Solid Supported Bilayer Lipid Membrane

doi: 10.1088/1674-0068/17/2/206-210
Funds:  Project supported by the National Natural Science Foundation of China(20343003)and the Fund of President of Graduate School of Chinese Academy of Sciences.
  • Received Date: 2003-08-25
  • The electrochemical biosensor properties of the molecular devices based on solid supported bilayer lipid membranes were investigated. The results showed that the system embedded with antihistaminic agent had strong response for the histamine. The response currents for the histamine will rise following the increasing concentrations of the histamine,as a result of the special opposing effect between histamine and antihistamine. Near the normal physiological condition(pH=7. 5),a good linearity occurred for the current response against histamine concentration ranging from 3. 0 to 60. 0 μg / L,and the relation coefficient R is 0. 9878. All the experiments mentioned above showed good sensitivity,selectivity and stability. This system can measure the concentration of histamine under -200 mV by voltammetry and be expected to form the electrochemical biosensor with high stability and low detection limit.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Studies of Electrochemical Sensoral Behavior of Histamine Based on the Solid Supported Bilayer Lipid Membrane

doi: 10.1088/1674-0068/17/2/206-210
Funds:  Project supported by the National Natural Science Foundation of China(20343003)and the Fund of President of Graduate School of Chinese Academy of Sciences.

Abstract: The electrochemical biosensor properties of the molecular devices based on solid supported bilayer lipid membranes were investigated. The results showed that the system embedded with antihistaminic agent had strong response for the histamine. The response currents for the histamine will rise following the increasing concentrations of the histamine,as a result of the special opposing effect between histamine and antihistamine. Near the normal physiological condition(pH=7. 5),a good linearity occurred for the current response against histamine concentration ranging from 3. 0 to 60. 0 μg / L,and the relation coefficient R is 0. 9878. All the experiments mentioned above showed good sensitivity,selectivity and stability. This system can measure the concentration of histamine under -200 mV by voltammetry and be expected to form the electrochemical biosensor with high stability and low detection limit.

Cai Hong, Zhang Zhanjun, Wang Bin, Li Yuhui, Cai Shengmin. Studies of Electrochemical Sensoral Behavior of Histamine Based on the Solid Supported Bilayer Lipid Membrane[J]. Chinese Journal of Chemical Physics , 2004, 17(2): 206-210. doi: 10.1088/1674-0068/17/2/206-210
Citation: Cai Hong, Zhang Zhanjun, Wang Bin, Li Yuhui, Cai Shengmin. Studies of Electrochemical Sensoral Behavior of Histamine Based on the Solid Supported Bilayer Lipid Membrane[J]. Chinese Journal of Chemical Physics , 2004, 17(2): 206-210. doi: 10.1088/1674-0068/17/2/206-210

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