Alginate-Coated Fe3O4 Hollow Microspheres for Drug Delivery
- Received Date: 2014-11-02
Abstract: Novel hollow Fe3O4 nanoparticles for drug delivery were synthesized via a one-step templatefree approach. These nanoparticles were obtained by modifing the Fe3O4 nanoparticles with 3-aminopropyltrimethoxy silane, and then grafting alginate onto the surface of amine magnetic. The hollow structure of Fe3O4 spheres was characterized by TEM, XRD, and XPS. The M-H hysteresis loop indicated that the magnetic spheres exhibit superparamagnetic characteristics at room temperature. Daunorubicin acting as a model drug was loaded into the carrier, and the maximum percent of envelop and load were 28.4% and 14.2% respectively. The drug controlled releasing behaviors of the carriers were compared in different pH media.
|Citation:||Li-juan Dong, Gu Jin. Alginate-Coated Fe3O4 Hollow Microspheres for Drug Delivery[J]. Chinese Journal of Chemical Physics , 2015, 28(2): 193-196. doi: 10.1063/1674-0068/28/cjcp1411191|