Synthesis of an Amphiphilic Dendrimer-Like Block Copolymer and Its Application on Drug Delivery
- Received Date: 2014-04-14
- Anionic ring opening polymerization, Living polymerization, Dendrimer-like copolymer, Amphiphilic diblock copolymer, Drug delivery
Abstract: Dendrimer-like amphiphilic copolymer is a kind of three-dimensional spherical structure polymer. An amphiphilic dendrimer-like diblock copolymer, PEEGE-G2-b-PEO(OH)12, constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were charac-terized with 1H NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH)12 using DOX as a model drug was also studied. The drug loading content and encapsulation e ciency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media.
|Citation:||Shuai-peng Wang, Xiao-wan Song, Xiao-shuang Feng, Peng Chen, Jia-sheng Qian, Ru Xia, Ji-bin Miao. Synthesis of an Amphiphilic Dendrimer-Like Block Copolymer and Its Application on Drug Delivery[J]. Chinese Journal of Chemical Physics , 2014, 27(5): 587-592. doi: 10.1063/1674-0068/27/05/587-592|