Dynamics of Micelle Formation from Mixed Lipid Droplets
- Received Date: 2012-10-23
- Dipalmitoylphosphatidylcholine, Hexadecylphosphocholine, Molecular dynam-ics, Lipid droplet, Self-assembly
Abstract: Amphiphilic lipid molecules can form various micelles depending on not only their molecular composition but also their self-assembly pathway. In this work, coarse-grained molecular dynamics simulations have been applied to study the micellization behaviors of mixed di-palmitoylphosphatidylcholine (DPPC)/hexadecylphosphocholine (HPC) droplets. By vary-ing DPPC/HPC composition and the size of lipid droplets, various micelles such as spherical and nonspherical (oblate or prolate) vesicles, disk-like micelles, double or single ring-like and worm-like micelles were observed. It is found that the lipid droplet as an initial state favors forming vesicles and ring-like micelles due to in situ micellization. Our simulation results demonstrate that using special initial conditions combined with various molecular compositions is an effective way to tune lipid micellar structure.
|Citation:||Rui Xu, Zi-lu Wang, Hua-ping Li, Xue-hao He. Dynamics of Micelle Formation from Mixed Lipid Droplets[J]. Chinese Journal of Chemical Physics , 2013, 26(2): 203-210. doi: 10.1063/1674-0068/26/02/203-210|