Chang-chun Hao, Run-guang Sun, Jing Zhang. Interaction of Egg-Sphingomyelin with DOPC in Langmuir Monolayers[J]. Chinese Journal of Chemical Physics , 2012, 25(6): 691-696. doi: 10.1088/1674-0068/25/06/691-696
Citation: Chang-chun Hao, Run-guang Sun, Jing Zhang. Interaction of Egg-Sphingomyelin with DOPC in Langmuir Monolayers[J]. Chinese Journal of Chemical Physics , 2012, 25(6): 691-696. doi: 10.1088/1674-0068/25/06/691-696

Interaction of Egg-Sphingomyelin with DOPC in Langmuir Monolayers

doi: 10.1088/1674-0068/25/06/691-696
Funds:  This work was supported by the Natural Science Basic Research Plan in Shaanxi Province of China (No.2012JQ1002) and the Fundamental Research Funds for the Central Universities (No.GK201102029).
  • Received Date: 2012-09-08
  • Lipid rafts are a dynamic microdomain structure found in recent years, enriched in sphin-golipids, cholesterol and particular proteins. The change of structure and function of lipid rafts could result in many diseases. In this work, the monolayer miscibility behavior of mixed systems of Egg-Sphingomyelin (ESM) with 1, 2-dioleoyl-sn-glycero-3-phosphocholine was in-vestigated in terms of mean surface area per molecule and excess molecular area ΔAex at certain surface pressure, surface pressure and excess surface pressure Δπex at certain mean molecular area. The stability and compressibility of the mixed monolayers was assessed by the parameters of surface excess Gibbs free energy ΔGex, excess Helmholtz energy ΔHex and elasticity. Thermodynamic analysis indicates ΔAex and Δπeex in the binary systems with positive deviations from the ideal behavior, suggesting repulsive interaction. The max-imum of ΔGex and ΔHex was at the molar fraction of ESM of 0.6, demonstrating the mixed monolayer was more unstable. The repulsive interaction induced phase separation in the monolayer
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Interaction of Egg-Sphingomyelin with DOPC in Langmuir Monolayers

doi: 10.1088/1674-0068/25/06/691-696
Funds:  This work was supported by the Natural Science Basic Research Plan in Shaanxi Province of China (No.2012JQ1002) and the Fundamental Research Funds for the Central Universities (No.GK201102029).

Abstract: Lipid rafts are a dynamic microdomain structure found in recent years, enriched in sphin-golipids, cholesterol and particular proteins. The change of structure and function of lipid rafts could result in many diseases. In this work, the monolayer miscibility behavior of mixed systems of Egg-Sphingomyelin (ESM) with 1, 2-dioleoyl-sn-glycero-3-phosphocholine was in-vestigated in terms of mean surface area per molecule and excess molecular area ΔAex at certain surface pressure, surface pressure and excess surface pressure Δπex at certain mean molecular area. The stability and compressibility of the mixed monolayers was assessed by the parameters of surface excess Gibbs free energy ΔGex, excess Helmholtz energy ΔHex and elasticity. Thermodynamic analysis indicates ΔAex and Δπeex in the binary systems with positive deviations from the ideal behavior, suggesting repulsive interaction. The max-imum of ΔGex and ΔHex was at the molar fraction of ESM of 0.6, demonstrating the mixed monolayer was more unstable. The repulsive interaction induced phase separation in the monolayer

Chang-chun Hao, Run-guang Sun, Jing Zhang. Interaction of Egg-Sphingomyelin with DOPC in Langmuir Monolayers[J]. Chinese Journal of Chemical Physics , 2012, 25(6): 691-696. doi: 10.1088/1674-0068/25/06/691-696
Citation: Chang-chun Hao, Run-guang Sun, Jing Zhang. Interaction of Egg-Sphingomyelin with DOPC in Langmuir Monolayers[J]. Chinese Journal of Chemical Physics , 2012, 25(6): 691-696. doi: 10.1088/1674-0068/25/06/691-696

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