Volume 34 Issue 5
Oct.  2021
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Yang-yi Liu, Hai-feng Pan, Jian-hua Xu, Jin-quan Chen. Long Chain Fatty Acid Affects Excited State Branching in Bilirubin-Human Serum Protein Complex†[J]. Chinese Journal of Chemical Physics , 2021, 34(5): 621-627. doi: 10.1063/1674-0068/cjcp2012220
Citation: Yang-yi Liu, Hai-feng Pan, Jian-hua Xu, Jin-quan Chen. Long Chain Fatty Acid Affects Excited State Branching in Bilirubin-Human Serum Protein Complex[J]. Chinese Journal of Chemical Physics , 2021, 34(5): 621-627. doi: 10.1063/1674-0068/cjcp2012220

Long Chain Fatty Acid Affects Excited State Branching in Bilirubin-Human Serum Protein Complex

doi: 10.1063/1674-0068/cjcp2012220
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  • After binding to human serum albumin, bilirubin could undergo photo-isomerization and photo-induced cyclization process. The latter process would result the formation of a product, named as lumirubin. These photo induced behaviors are the fundamental of clinical therapy for neonatal jaundice. Previous studies have reported that the addition of long chain fatty acids is beneficial to the generation of lumirubin, yet no kinetic study has revealed the mechanism behind. In this study, how palmitic acid affects the photochemical reaction process of bilirubin in Human serum albumin (HSA) is studied by using femtosecond transient absorption and fluorescence up-conversion techniques. With the addition of palmitic acid, the excited population of bilirubin prefers to return to its hot ground state (S0) through a 4 ps decay channel rather than the intrinsic ultrafast decay pathways (< 1 ps). This effect prompts the Z-Z to E-Z isomerization at the S$_0$ state and then further increases the production yield of lumirubin. This is the first time to characterize the promoting effect of long chain fatty acid in the process of phototherapy with femtosecond time resolution spectroscopy and the results can provide useful information to benefit the relevant clinical study.


  • Part of special topic of "the Young Scientist Forum on Chemical Physics: Ultrafast Dynamics of Photoelectric Conversion Workshop 2020".
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