Long Chain Fatty Acid Affects Excited State Branching in Bilirubin-Human Serum Protein Complex<sup>†</sup>

Yang-yi Liu; Hai-feng Pan; Jian-hua Xu; Jin-quan Chen

doi:10.1063/1674-0068/cjcp2012220

Volume 34 Issue 5

Oct. 2021

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Yang-yi Liu, Hai-feng Pan, Jian-hua Xu, Jin-quan Chen. Long Chain Fatty Acid Affects Excited State Branching in Bilirubin-Human Serum Protein Complex†[J]. Chinese Journal of Chemical Physics , 2021, 34(5): 621-627. doi: 10.1063/1674-0068/cjcp2012220

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Yang-yi Liu, Hai-feng Pan, Jian-hua Xu, Jin-quan Chen. Long Chain Fatty Acid Affects Excited State Branching in Bilirubin-Human Serum Protein Complex^†[J]. Chinese Journal of Chemical Physics , 2021, 34(5): 621-627. doi: 10.1063/1674-0068/cjcp2012220

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Long Chain Fatty Acid Affects Excited State Branching in Bilirubin-Human Serum Protein Complex^†

doi: 10.1063/1674-0068/cjcp2012220

Yang-yi Liu^a,
Hai-feng Pan^{a
,
,},
Jian-hua Xu^{a, b},
Jin-quan Chen^{a, b
,
,}

a.
State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200241, China
b.
Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, China

More Information

Corresponding author: Hai-feng Pan, E-mail: hfpan@phy.ecnu.edu.cn; Jin-quan Chen, E-mail: jqchen@lps.ecnu.edu.cn
Received Date: 2021-12-31
Accepted Date: 2021-01-19
Publish Date: 2021-10-27

Abstract

Abstract

After binding to human serum albumin, bilirubin could undergo photo-isomerization and photo-induced cyclization process. The latter process would result the formation of a product, named as lumirubin. These photo induced behaviors are the fundamental of clinical therapy for neonatal jaundice. Previous studies have reported that the addition of long chain fatty acids is beneficial to the generation of lumirubin, yet no kinetic study has revealed the mechanism behind. In this study, how palmitic acid affects the photochemical reaction process of bilirubin in Human serum albumin (HSA) is studied by using femtosecond transient absorption and fluorescence up-conversion techniques. With the addition of palmitic acid, the excited population of bilirubin prefers to return to its hot ground state (S₀) through a 4 ps decay channel rather than the intrinsic ultrafast decay pathways (< 1 ps). This effect prompts the Z-Z to E-Z isomerization at the S$_0$ state and then further increases the production yield of lumirubin. This is the first time to characterize the promoting effect of long chain fatty acid in the process of phototherapy with femtosecond time resolution spectroscopy and the results can provide useful information to benefit the relevant clinical study.
- Bilirubin,
- Human serum albumin,
- Femtosecond transient absorption,
- Excited state dynamics

^†Part of special topic of "the Young Scientist Forum on Chemical Physics: Ultrafast Dynamics of Photoelectric Conversion Workshop 2020".

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References(30)

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