Volume 33 Issue 3
Jul.  2020
Turn off MathJax
Article Contents
Shan Lei, Li-an Wang, Fu-xing Lin, Kun Zeng, Mo-zhen Wang, Mo-zhen Wang. Magnetic Nano-Amorphous-Iron-Oxide-Based Drug Delivery System with Dual Therapeutic Mechanisms[J]. Chinese Journal of Chemical Physics , 2020, 33(3): 376-384. doi: 10.1063/1674-0068/cjcp1906123
Citation: Shan Lei, Li-an Wang, Fu-xing Lin, Kun Zeng, Mo-zhen Wang, Mo-zhen Wang. Magnetic Nano-Amorphous-Iron-Oxide-Based Drug Delivery System with Dual Therapeutic Mechanisms[J]. Chinese Journal of Chemical Physics , 2020, 33(3): 376-384. doi: 10.1063/1674-0068/cjcp1906123

Magnetic Nano-Amorphous-Iron-Oxide-Based Drug Delivery System with Dual Therapeutic Mechanisms

doi: 10.1063/1674-0068/cjcp1906123
More Information
  • Corresponding author: Fu-xing Lin, E-mail:20180105@fjsmu.edu.cn Tel: +86-598-8397900; Mo-zhen Wang, E-mail: pstwmz@ustc.edu.cn Tel: +86-551-63600843
  • Received Date: 2019-06-28
  • Accepted Date: 2019-08-16
  • Publish Date: 2020-06-27
  • Smart nanoparticles that respond to pathophysiological parameters, such as pH, GSH, and H$ _2 $O$ _2 $, have been developed with the huge and urgent demand for the high-efficient drug delivery systems (DDS) for cancer therapy. Herein, cubic poly(ethylene glycol) (PEG)-modified mesoporous amorphous iron oxide (AFe) nanoparticles (AFe-PEG) have been successfully prepared as pH-stimulated drug carriers, which can combine doxorubicin (DOX) with a high loading capacity of 948 mg/g, forming a novel multifunctional AFe-PEG/DOX nanoparticulate DDS. In an acidic microenvironment, the AFe-PEG/DOX nanoparticles will not only release DOX efficiently, but also release Fe ions to catalyze the transformation of H$ _2 $O$ _2 $ to $ \cdot $OH, acting as fenton reagents. In vitro experimental results proved that the AFe-PEG/DOX nanoparticles can achieve combination of chemotherapeutic (CTT) and chemodynamic therapeutic (CDT) effects on Hela tumor cells. Furthermore, the intrinsic magnetism of AFe-PEG/DOX makes its cellular internalization efficiency be improved under an external magnetic field. Therefore, this work develops a new and promising magnetically targeted delivery and dual CTT/CDT therapeutic nano-medicine platform based on amorphous iron oxide.

     

  • loading
  • [1]
    O. Rozenfeld, Y. Koltypin, H. Bamnolker, S. Margel, and A. Gedanken, Langmuir, 10, 3919 (1994). doi: 10.1021/la00023a001
    [2]
    T. Iwamoto, Biol. Pharm. Bull. 36, 715 (2013). doi: 10.1248/bpb.b12-01102
    [3]
    D. Peer, J. M. Karp, S. Hong, O. C. Farokhzad, R. Margalit, and R. Langer, Nat. Nanotechnol. 2, 751 (2007). doi: 10.1038/nnano.2007.387
    [4]
    R. Mo, T. Jiang, R. DiSanto, W. Tai, and Z. Gu, Nat. Commun. 5, 3364 (2014). doi: 10.1038/ncomms4364
    [5]
    T. M. Sun, Y. S. Zhang, B. Pang, D. C. Hyun, M. X. Yang, and Y. N. Xia, Angew. Chem. Int. Ed. 53, 12320 (2014).
    [6]
    X. W. Zeng, G. Liu, W. Tao, Y. Ma, X. D. Zhang, F. He, J. M. Pan, L. Mei, and G. Q. Pan, Adv. Funct. Mater. 27, 1605985 (2017). doi: 10.1002/adfm.201605985
    [7]
    L. Huang, L. Ao, D. H. Hu, W. Wang, Z. H. Sheng, and W. Su, Chem. Mater. 28, 5896 (2016). doi: 10.1021/acs.chemmater.6b02413
    [8]
    X. J. Cai, X. Q. Jia, W. Gao, K. Zhang, M. Ma, S. G. Wang, Y. Y. Zheng, J. L. Shi, and H. R. Chen, Adv. Funct. Mater. 25, 2520 (2015). doi: 10.1002/adfm.201403991
    [9]
    X. J. Cai, W. Gao, M. Ma, M. Y. Wu, L. L. Zhang, Y. Y. Zheng, H. R. Chen, and J. L. Shi, Adv. Mater. 27, 6382 (2015). doi: 10.1002/adma.201503381
    [10]
    S. Mura, J. Nicolas, and P. Couvreur, Nat. Mater. 12, 991 (2013). doi: 10.1038/nmat3776
    [11]
    H. J. Xiang, H. Lin, L. D. Yu, and Y. Chen, ACS Nano 13, 2223 (2019).
    [12]
    W. X. Sun, H. T. Jiang, X. Wu, Z. Y. Xu, C. Yao, J. Wang, M. Qin, Q. Jiang, W. Wang, D. Q. Shi, and Y. Cao, Nano Res. 12, 115 (2018).
    [13]
    Y. X. Guo, Y. Zhang, J. Y. Ma, Q. Li, Y. Li, X. Y. Zhou, D. Zhao, H. Song, Q. Chen, and X. Zhu, J. Control. Release 272, 145 (2018). doi: 10.1016/j.jconrel.2017.04.028
    [14]
    P. Mi, D. Kokuryo, H. Cabral, H. L. Wu, Y. Terada, T. Saga, I. Aoki, N. Nishiyama, and K. Kataoka, Nat. Nanotechnol. 11, 724 (2016). doi: 10.1038/nnano.2016.72
    [15]
    S. Lei, J. X. Chen, K. Zeng, M. Z. Wang, and X. W. Ge, Nano Res. 12, 1071 (2019). doi: 10.1007/s12274-019-2348-1
    [16]
    C. M. Yu, L. H. Qian, J. Y. Ge, J. Q. Fu, P. Y. Yuan, S. C. L. Yao, and S. Q. Yao, Angew. Chem. Int. Ed. 55, 9272 (2016). doi: 10.1002/anie.201602188
    [17]
    Y. Q. Zhang, J. Q. Wang, J. C. Yu, D. Wen, A. R. Kahkoska, Y. Lu, X. D. Zhang, J. B. Buse, and Z. Gu, Small 14, e1704181 (2018). doi: 10.1002/smll.201704181
    [18]
    M. Ahlen, G. K. Tummala, and A. Mihranyan, Int. J. Pharm. 536, 73 (2018). doi: 10.1016/j.ijpharm.2017.11.053
    [19]
    H. R. Wang, W. W. Zhu, J. J. Liu, Z. L. Dong, and Z. Liu, ACS Appl. Mater. Interfaces 10, 14475 (2018). doi: 10.1021/acsami.8b02080
    [20]
    X. D. Xue, Y. Huang, R. Bo, B. Jia, H. Wu, Y. Yuan, Z. L. Wang, Z. Ma, D. Jing, X. B. Xu, W. M. Yu, T. Y. Lin, and Y. P. Li, Nat. Commun. 9, 3653 (2018). doi: 10.1038/s41467-018-06093-5
    [21]
    X. Zhang, X. H. Xu, Y. C. Li, C. Hu, Z. J. Zhang, and Z. W. Gu, Adv. Mater. 30, e1707240 (2018). doi: 10.1002/adma.201707240
    [22]
    J. Z. Du, X. J. Du, C. Q. Mao, and J. Wang, J. Am. Chem. Soc. 133, 17560 (2011). doi: 10.1021/ja207150n
    [23]
    Q. Chen, C. Wang, X. D. Zhang, G. J. Chen, Q. Y. Hu, H. J. Li, J. Q. Wang, D. Wen, Y. Q. Zhang, Y. F. Lu, G. Yang, C. Jiang, J. Wang, G. Dotti, and Z. Gu, Nat. Nanotechnol. 14, 89 (2019). doi: 10.1038/s41565-018-0319-4
    [24]
    J. Nam, S. Son, L. J. Ochyl, R. Kuai, A. Schwendeman, and J. J. Moon, Nat. Commun. 9, 1074 (2018). doi: 10.1038/s41467-018-03473-9
    [25]
    Y. L. Dai, Z. Yang, S. Y. Cheng, Z. Y. Wang, R. L. Zhang, G. Z. Zhu, Z. T. Wang, B. C. Yung, R. Tian, O. Jacobson, C. Xu, Q. Q. Ni, J. B. Song, X. L. Sun, G. Niu, and X. Y. Chen, Adv. Mater. 30, 1704877 (2018). doi: 10.1002/adma.201704877
    [26]
    J. X. Chen, S. Lei, K. Zeng, M. Z. Wang, A. Asif, and X. W. Ge, Nano Res. 10, 2351 (2017). doi: 10.1007/s12274-017-1431-8
    [27]
    M. Hu, S. Furukawa, R. Ohtani, H. Sukegawa, Y. Nemoto, J. Reboul, S. Kitagawa, and Y. Yamauchi, Angew. Chem. Int. Ed. 51, 984 (2012). doi: 10.1002/anie.201105190
    [28]
    M. Hu, A. A. Belik, M. Imura, K. Mibu, Y. Tsujimoto, and Y. Yamauchi, Chem. Mater. 24, 2698 (2012). doi: 10.1021/cm300615s
    [29]
    J. L. Shi, Nanomedicine 11, 1189 (2016) doi: 10.2217/nnm-2016-0039
    [30]
    L. Zhang, H. B. Wu, S. Madhavi, H. H. Hng, and X. W. Lou, J. Am. Chem. Soc. 134, 17388 (2012). doi: 10.1021/ja307475c
    [31]
    K. S. W. Sing, Pure Appl. Chem. 57, 603 (1985). doi: 10.1351/pac198557040603
    [32]
    S. Brunauer, L. S. Deming, W. E. Deming, and E. Teller, J. Am. Chem. Soc. 62, 1723 (1940). doi: 10.1021/ja01864a025
    [33]
    Y. F. Zhu, J. L. Shi, W. H. Shen, X. P. Dong, J. W. Feng, M. L. Ruan, and Y. S. Li, Angew. Chem. Int. Ed. 44, 5083 (2005). doi: 10.1002/anie.200501500
    [34]
    W. R. Zhao, H. R. Chen, Y. S. Li, L. Li, M. D. Lang, and J. L. Shi, Adv. Funct. Mater. 18, 2780 (2008). doi: 10.1002/adfm.200701317
    [35]
    Y. Chen, H. R. Chen, D. P. Zeng, Y. B. Tian, F. Chen, J. W. Feng, and J. L. Shi, ACS Nano 4, 6001 (2010). doi: 10.1021/nn1015117
    [36]
    F. X. Lin, K. Zeng, W. X. Yang, M. Z. Wang, J. L. Rong, J. Xie, Y. Zhao, and X. W. Ge, Chin. J. Chem. Phys. 30, 231 (2017). doi: 10.1063/1674-0068/30/cjcp1609185
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(14)

    Article Metrics

    Article views (112) PDF downloads(16) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return