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ChenWenjun. Detection of tetracycline antibiotics in water by dispersive micro-solid phase extraction using Fe3O4@[Cu3(btc)2] magnetic composite combined with liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chemical Physics .
Citation: ChenWenjun. Detection of tetracycline antibiotics in water by dispersive micro-solid phase extraction using Fe3O4@[Cu3(btc)2] magnetic composite combined with liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chemical Physics .

Detection of tetracycline antibiotics in water by dispersive micro-solid phase extraction using Fe3O4@[Cu3(btc)2] magnetic composite combined with liquid chromatography-tandem mass spectrometry

  • Accepted Date: 2020-07-02
  • Residues of tetracycline antibiotics (TCs) in environments may be harmful to human. Due to their high polarities, it is extremely challenging to efficiently enrich TCs with low concentrations in natural waters for analysis. In this work, a magnetic metal-organic framework (MOF) Fe3O4@[Cu3(btc)2] was synthesized and applied as a dispersive micro-solid phase extraction (DMSPE) adsorbent for TCs enrichment. Effects of DMSPE conditions including extraction time, solution pH, and elution solvent on the extraction efficiencies of TCs were investigated. Results show that TCs could be enriched efficiently by Fe3O4@[Cu3(btc)2], and electrostatic interaction between TCs and Fe3O4@[Cu3(btc)2] dominated this process. Combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS), four TCs residues (oxytetracycline, tetracycline, chlortetracycline, and doxycycline) in natural waters were determined. The detection limits (LOD, S/N=3) of the four antibiotics were 0.01-0.02 μg/L, and the limits of quantitation (LOQ, S/N=10) were 0.04-0.07 μg/L. The recoveries obtained from river water and aquaculture water spiked with three TCs concentration levels ranged from 70.3-96.5% with relative standard deviations of 3.8-12.8%. Results indicate that the magnetic MOFs based DMSPE is simple, rapid and high-loading for antibiotics enrichment from water, which further expand the practical application of MOFs in sample pretreatment for environmental pollutant analysis.
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通讯作者: 陈斌, bchen63@163.com
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Detection of tetracycline antibiotics in water by dispersive micro-solid phase extraction using Fe3O4@[Cu3(btc)2] magnetic composite combined with liquid chromatography-tandem mass spectrometry

Abstract: Residues of tetracycline antibiotics (TCs) in environments may be harmful to human. Due to their high polarities, it is extremely challenging to efficiently enrich TCs with low concentrations in natural waters for analysis. In this work, a magnetic metal-organic framework (MOF) Fe3O4@[Cu3(btc)2] was synthesized and applied as a dispersive micro-solid phase extraction (DMSPE) adsorbent for TCs enrichment. Effects of DMSPE conditions including extraction time, solution pH, and elution solvent on the extraction efficiencies of TCs were investigated. Results show that TCs could be enriched efficiently by Fe3O4@[Cu3(btc)2], and electrostatic interaction between TCs and Fe3O4@[Cu3(btc)2] dominated this process. Combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS), four TCs residues (oxytetracycline, tetracycline, chlortetracycline, and doxycycline) in natural waters were determined. The detection limits (LOD, S/N=3) of the four antibiotics were 0.01-0.02 μg/L, and the limits of quantitation (LOQ, S/N=10) were 0.04-0.07 μg/L. The recoveries obtained from river water and aquaculture water spiked with three TCs concentration levels ranged from 70.3-96.5% with relative standard deviations of 3.8-12.8%. Results indicate that the magnetic MOFs based DMSPE is simple, rapid and high-loading for antibiotics enrichment from water, which further expand the practical application of MOFs in sample pretreatment for environmental pollutant analysis.

ChenWenjun. Detection of tetracycline antibiotics in water by dispersive micro-solid phase extraction using Fe3O4@[Cu3(btc)2] magnetic composite combined with liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chemical Physics .
Citation: ChenWenjun. Detection of tetracycline antibiotics in water by dispersive micro-solid phase extraction using Fe3O4@[Cu3(btc)2] magnetic composite combined with liquid chromatography-tandem mass spectrometry[J]. Chinese Journal of Chemical Physics .

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